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. 2013 Nov 12;42(3):1733–1746. doi: 10.1093/nar/gkt1117

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Whole-genome sequencing provides an accurate measurement of telomeric content. (A) TRF analysis of telomere length in mortal, ALT and telomerase-positive cell lines. (B) Correlation between telomere length measured by densitometric quantitation of TRF and telomere content measured by normalized read count in mortal, ALT and telomerase cell lines. AG11395 and U2OS were excluded from this analysis due to inaccuracies in densitometric TRF quantitation caused by telomeric SV40 sequences in AG11395 and exceptionally long telomeres in U2OS. (C) Comparison of telomere repeat content measured by normalized telomere read count (4× consecutive TTAGGG), TRF analysis, dot blot, qPCR using 2009 published primers (31) and qPCR using 2002 published primers (32), relative to the HeLa cell line.