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. 2013 Oct 31;42(3):1442–1460. doi: 10.1093/nar/gkt938

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Model of possible Hap4-dependent phosphorylation in oleate. (A) The four regulators surrounded by the dotted red line were identified by the yeast EGRIN in Level 2 as shown in Table 2. The four regulators surrounded by the dotted black line are the well-studied AOPY peroxisome regulatory motif (18,73). The microscopy phenotypes are peroxisome growth observation taken from (17) and (75). The interactions between Snf1 and Gcl7, which promote phosphorylation of Adr1 and induction of peroxisomal genes through the AOPY motif, are discussed in (76,77) and are indicated by the starred green circle. The feedback is discussed in the text. (B) The evidence for the Hap4p and Cat8p regulation. Motif, ChIP-chip and Shatter show estimated P-values as detailed. may be considered strong evidence, may be considered weak evidence and P = 1 are labeled ‘−’and are considered no evidence. The Δ Log2 Ratio is the change in log₂ expression ratio versus wild type at the appropriate time point when CAT8 or HAP4 is deleted. (C) Shows the log₂ expression ratios versus LS wild type in oleate induction batch culture experiments.

Inline graphic — Model of possible Hap4-dependent phosphorylation in oleate. (A) The four regulators surrounded by the dotted red line were identified by the yeast EGRIN in Level 2 as shown in Table 2. The four regulators surrounded by the dotted black line are the well-studied AOPY peroxisome regulatory motif (18,73). The microscopy phenotypes are peroxisome growth observation taken from (17) and (75). The interactions between Snf1 and Gcl7, which promote phosphorylation of Adr1 and induction of peroxisomal genes through the AOPY motif, are discussed in (76,77) and are indicated by the starred green circle. The feedback is discussed in the text. (B) The evidence for the Hap4p and Cat8p regulation. Motif, ChIP-chip and Shatter show estimated P-values as detailed. may be considered strong evidence, may be considered weak evidence and P = 1 are labeled ‘−’and are considered no evidence. The Δ Log2 Ratio is the change in log₂ expression ratio versus wild type at the appropriate time point when CAT8 or HAP4 is deleted. (C) Shows the log₂ expression ratios versus LS wild type in oleate induction batch culture experiments.