Table 2.

Top predicted regulators of peroxisomes

Regulator	Total score	Type	Complex	Notes		Total score	Type	Complex	Notes
CAT8	173	TF			RAD14	77	DNA
MBR1	159	TF		Suppresses Hap 2–4 deletion	RAD2	47	DNA
GAL3	52	TF			RAD4	29	DNA	RAD23
SPS18	52	TF?		Putative	RAD55	21	DNA	RAD57
HAP4	48	TF	HAP 2–5		CBF5	12	DNA		Centromere binding factor
FZF1	43	TF			RAD18	10	DNA	RAD6
MIG1	41	TF		Regulated by SNF1 and GLC7	PHO88	74	Other		Membrane phosphate transport
RME1	36	TF	IME1	Cell cycle	MGA2	8	Other		Membrane OLE1 transcription
MSN4	30	TF		Stress response	SAS10	8	Other		Makes 18S rRNA
PIP2	29	TF			ATG16	8	Other		Authophagy
XBP1	27	TF		Repressor	HTB2	50	Histone
SEF1	26	TF		Putative	STB2	47	Histone	SIN3	Maybe TF or deacetylase
WTM1	26	TF	Ribosome		HTA2	22	Histone
RIM101	21	TF		Repressor	HAT1	9	Histone	HAT2
RGT1	17	TF		Activator and repressor	HHF1	6	Histone	HHF2	Telomeric silencing
SOK2	17	TF		Kinase regulator	RPO31	21	RNA	C160	RNA polymerase III
HMS1	14	TF			RPA135	16	RNA	A135	RNA polymerase I
RGM1	14	TF		Putative	RPC31	12	RNA	C31	RNA polymerase III
RPN4	12	TF		Proteasome activator	RPA43	10	RNA	A43	RNA polymerase I
DAL80	8	TF			RPO26	10	RNA	ABC23	RNA polymerase I,II,III
SUA7	8	TF		General transcription	RPA190	9	RNA	A190	RNA polymerase I
TEA1	6	TF		Ty1 enhancer activator	SRB5	8	RNA		RNA polymerase II
SIP2	161	Kinome	SNF1		RPC82	8	RNA	C82	RNA polymerase III
PCL10	79	Kinome	PHO85		RPC53	7	RNA	C53	RNA polymerase III
PCL8	24	Kinome	PHO85		RPA12	7	RNA	A12.2	RNA polymerase I
PCL7	22	Kinome	PHO85		RPA49	6	RNA	A49	RNA polymerase I
PCL5	6	Kinome	PHO85

Type refers to the type of regulator: TF, a transcription factor; Kinome, a member of a Phophatase or Kinase complex; Histone, a histone modification protein; DNA, a DNA repair protein. Sps18 is labeled ‘TF?’ to emphasize that it is not proven to be a TF. Complex shows some known interaction partners.