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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Gastroenterology. 2013 Sep 22;146(1):257–267. doi: 10.1053/j.gastro.2013.09.044

Figure 1.

Figure 1

Overexpression of Wnt1 ligand induces MCN-like lesions in KrasG12D transgenic mice. Multilocular cysts including serosanguinous contents are located in the pancreatic body and tail in elastase-tva, Ptf1a-cre, LSL-KrasG12D compound transgenic mice infected with RCAS-Wnt1 (A and C; arrows; sp, spleen). (B) Cut surface showing enlarged cyst with slightly thickened cyst wall and precipitation of old coagulation in the lumen (arrows). (D) A unilocular cyst containing hemorrhagic contents is observed in the pancreatic tail of an RCAS-Wnt1–injected elastase-tva, Ptf1a-cre, LSL-KrasG12D compound transgenic mouse (arrows). (E) Kaplan–Meier analysis demonstrates that RCAS-Wnt1–injected mice tended to have poor prognosis under cystic lesion-free survival curve *P = .052 by the log-rank test.