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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Gastroenterology. 2013 Sep 22;146(1):257–267. doi: 10.1053/j.gastro.2013.09.044

Figure 6.

Figure 6

Activation of Wnt/β-catenin signaling pathways in human MCN. (A) Nuclear accumulation of β-catenin is observed in the ovarian-like stoma of human MCN, but not in the cyst epithelium (asterisk). Nuclear translocation of p-JNK (B), p-Smad2 (C), and p-Rock2 (D) are seen in the ovarian-like stroma. (E) Strong expression of Wnt1 is seen focally in the cyst epithelium (arrows), and the ovarian-like stromal cells are diffusely positive for Wnt1. (F) Expression of the Wnt1 receptor FZD3 is observed in focal epithelial cells and in the ovarian-like stroma.