Ratings of fullness, discomfort, hunger, and desire for food (0–4) were obtained during the fMRI scan when the gastric balloon was empty (0 mL) or full (500 mL). Only the fullness ratings increased significantly (P = 0.005) when the balloon was full. (mean ± SE) Reproduced from: “Gastric distention activates satiety circuitry in the human brain,” by Wang, G. J., Tomasi, D., Backus, W., Wang, R., Telang, F., Geliebter, A., Korner, J., Bauman, A., Fowler, J. S., Thanos, P. K., Volkow, N. D. (2008). Neuroimage, 39(4), p.1827. Copyright 2008 by ELSEVIER INC. Reprinted with permission.