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. 2014 Feb 7;20:171–177.

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Copyright © 2014 Molecular Vision.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.

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Effect of echinochrome on nuclear factor κB (NFκB) p65 (red) activation in the iris/ciliary body 3 h after lipopolysaccharide injection is shown. Dual-immunofluorescence labeling showed NFκB colocalization (yellow) in nuclei (green). A: Control naïve animals were not injected with lipopolysaccharide (LPS); an inactive NFκB signal was observed only in the cytoplasm area of cells and no nuclear colocalization of NFκB was detected. B: The group of endotoxin-induced uveitis (EIU) rats treated with echinochrome showed reduced NFκB colocalization compared to C: untreated EIU rats. D: Quantitative analysis of NFκB-positive cells in the iris/ciliary body (ICB). Data are shown as mean±standard error of mean (SEM; n=4). *Amount of NFκB nuclear colocalization was significantly lower in echinochrome treated group than untreated EIU controls (p<0.05).