Figure 4. Anti-neuroblastoma activitiy of mAb c.8B6 against established experimental liver metastasis.
Mice (n = 6/group) were inoculated with 1×105 NXS2 cells by IV injections. Treatment was initiated three days after tumor cells inoculation and consisted of 5 daily IV injections of 25 µg of mAb c.8B6, mAb ch14.18, and anti-CD20 antibody. Mice were euthanised 28 days post-tumor cell inoculation. (A) The liver weight was determined on fresh specimen. The y-axis starts at 0.8 g corresponding to the average normal liver weight. Data are presented as the mean ± SEM. The differences in mean liver weight between experimental groups treated with mAbs c.8B6 and ch14.18 and all control groups (PBS, control antibody) was statistically significant (*p<0.05). (B) Representative liver specimen of each experimental group is shown. Arrows indicate the location of macroscopic liver metastasis. (Scale bar = 1 cm).