Figure 6. Intravenous injection of mAb c.8B6 does not induce allodynia.

(A) Intraveinous injection of either 1 mg/kg (•) or 3 mg/kg (♦)of mAb c.8B6 in Sprague-Dawley rats did not result in a decrease in mechanical thresholds. In contrast, ch14.18 injected at 1 mg/kg (▪) resulted in a prolonged decrease in threshold. Threshold of animal injected with anti-CD20 chimeric control antibody rituximab (1 mg/kg) (□) are shown for comparison. (B) Results shown in panel B were recalculated as area under the curve and then normalized such that 100 would be equal to a theoretical maximal allodynia. Animals administered ch14.18 displayed more allodynia than any of the other treatment groups (p≤ 0.0001).