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. 2014 Feb 10;9(2):e87208. doi: 10.1371/journal.pone.0087208

Figure 1. EN2 levels are elevated in individuals with autism and an A-C/G-T genotype.

Figure 1

EN2 mRNA levels were measured in 29 autism and 49 control cerebellar samples using Taqman qRT-PCR. Based on the interaction between genotype and affection status, EN2 levels were compared between genotypes (A-C/A-C, A-C/G-T, G-T/G-T) in control and autism groups separately. In each group EN2 levels are normalized to 1 for A-C/A-C genotype and presented as fold change for the other genotypes (EN2 levels are similar between control A-C/A-C and autism A-C/A-C group (<0.5% difference). Fold difference was calculated based on ΔΔCt values. Type 3 tests of fixed effects, *P<.05, **P<.01, ***P<.001, ****P<.0001. AC/AC – individuals homozygous for the rs1861972-rs1861973 A-C haplotype, GT/GT – individuals homozygous for the G-T haplotype, AC/GT – individuals heterozygous for the A-C/G-T haplotype.