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. 2014 Feb 10;9(2):e87999. doi: 10.1371/journal.pone.0087999

Figure 4. Influence of age on daily rhythms of plasma CORT in air or CS-exposed mice.

Figure 4

Adult mice (8–10 weeks old at start of CS exposure) were exposed to air or CS for 3 days (young), 10 days (young) and 6 months (middle aged). Plasma levels of CORT were determined by ELISA. Gray shading indicates the subjective dark phase (ZT12 and ZT18). Data from air- and CS-exposed mice are shown as mean ± SEM (n = 3–7 mice per group). Data were analyzed with non-linear regression (multi-order polynomial) analyses. + P<0.05; + + + P<0.001 significant compared to 3 days air- or CS-exposed mice; # # P<0.01; # # # P<0.001 significant compared to 10 days air-exposed mice.