Figure 4. C-sweat secretion (+) ivacaftor in CF subject 3: female, F508del/G551D.

S4 was tested only once, (+) ivacaftor. (A) Gland-by-gland correlations of M- and C-sweating using the same conventions as above. M-sweat was measured for 90 glands of which 21 also produced C-sweat with C/M ratios of 0.3% to 5% of the mean WT ratio. (B) Volume vs. time plots for C-sweating of each responding gland. β-adrenergic cocktail injected at time 0, and no observations were made during the first 3 min when atropine was taking effect and when the site was rinsed and dried before reapplying oil. Note slow time course of response.