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. 2014 Feb 10;9(2):e88617. doi: 10.1371/journal.pone.0088617

Figure 4. Antidepressant-like effect of Radix Polygalae is associated with phosphorylation of hippocampal AMPA receptor GluR1 but not mTOR.

Figure 4

(A) RP treatment (0.1 mg/kg p.o.) reduced hippocampal GluR1 phosphorylation (S845) but not when RP was co-administered with NBQX (10 mg/kg, i.p.) [F(2,15) = 4.38, p = 0.032]. There was no significant change in total GluR1 levels. (B) There was no significant effect on hippocampal phospho-mTOR (S2448) and total mTOR expression by RP or of RP + NBQX. Vehicle: distilled water, RP: Radix Polygalae. All data represent mean ± SEM. ANOVA, Tukey's post hoc test.