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. 2014 Feb 10;9(2):e88672. doi: 10.1371/journal.pone.0088672

Figure 1. The CB1 agonist WIN 55,212-2 enhances up-state amplitude and spiking.

Figure 1

A, example traces from the same neuron before and after application of WIN (1 µM) and summary data from these experiments. In graphs, connected points represent data from the same neuron. B, comparison of the change in up-state parameters following WIN treatment in wt and CB1 KO cultures. Bars represent mean ± SEM of difference scores for each measure of up-states (N = 7 cells). Symbols: *p<0.05, **p<0.01, and ***p<0.001.