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. 2014 Feb 10;9(2):e88739. doi: 10.1371/journal.pone.0088739

Figure 2. Weight chart and grip strength analysis of NT-1654 and vehicle treated SARCO mice.

Figure 2

A: Weight recording of wild type littermates (Control), SARCO mice treated with NT-1654 (SARCO treated) and vehicle treated SARCO mice (SARCO). Treatment started at P8 s.c. with 10 mg/kg per day and ended at P30. Weight was recorded every day before the next dose was applied. For control, littermates (SARCO and Control) were simultaneously injected with PBS (vehicle). Starting at day 20, treated SARCO mice gain substantially more weight than the non-treated SARCO littermates. From day 21 on, the difference in weight became significant (*, p<0.05). Number of animals: wt  =  11; SARCO treated  =  9, SARCO  =  6. B: Grip strength measurements of Controls, SARCO mice treated with NT-1654 and SARCO mice at P30, the last day of compound administration. Bars represent mean values ± standard deviation. Treated SARCO mice showed significantly increased grip strength compared to the non-treated SARCO littermates. The forelimb strength reverted fully to Control level whereas the hindlimb strength was intermediate between wild type and SARCO mice. Number of animals: wt  =  11; SARCO treated  =  9, SARCO  =  6. * p<0.05; ** p<0.01.