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. Author manuscript; available in PMC: 2014 Feb 10.
Published in final edited form as: Compr Physiol. 2012 Apr;2(2):1303–1353. doi: 10.1002/cphy.c110041

Figure 10. Control of HSP expression in response to cell stress.

Figure 10

Shown are the known actions of the constitutively expressed Hsps, primarily of the Hsp70 family called heat shock congnates (HSC) in processing cellular functions. Cell stress increases denatured proteins increasing the demand for HSC. Heat shock transcription factor (HSF), reversibly binds to HSC and is released with the increased demand for HSC. HSF then rapidly initiates transcription for all inducible Hsps including Hsp 70 and Hsp 25/27. Figure from citation (521).