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. 2014 Feb 10;9(2):e88644. doi: 10.1371/journal.pone.0088644

Figure 1. Acacetin inhibits 4-AP and KCl-evoked glutamate release from rat hippocampal nerve terminals in a concentration-dependent manner.

Figure 1

A: Chemical structure of acacetin. B, C: Glutamate release was measured under control conditions or in the presence of 30 µM acacetin added 10 min prior to the addition of 4-AP (1 mM) or KCl (15 mM). D: Dose-response curves of decrease in 4-AP or KCl-evoked glutamate release in the presence of acacetin. Results are mean ± SEM of independent experiments, using synaptosomal preparations from six animals. ***, P<0.001 versus control group.