Figure 5. Acacetin suppresses KA-induced microglial activation in the CA3 region of the hippocampus.

Acacetin (10 or 50 mg/kg, i.p.) was administrated 30 min before KA injection, and the hippocampal sections were stained with anti-OX-42 antibody at 3 days after KA injection. Representative photomicrographs illustrating OX-42 immunoreactivity in the hippocampal CA3 region of control, KA, KA + acacetin 10 mg/kg, and KA + acacetin 50 mg/kg. Insets in figure show the morphological changes after KA administration under higher magnification. Representative picture from six independent experiments were presented. Scale bar  = 100 µm for A-D.