Figure 1. Putative microglial filopodial protrusions contacting synaptic elements in a mouse model of HIV-associated neurocognitive disorder (HAND). A-B: Filopodia from the same cell (shown by the arrows in A) are simultaneously targeting three asymmetrical synapses between axon terminals (t) and dendritic spines (s). C: A putative microglial process that contains a vacuole (v) is simultaneously touching a dendritic spine and a symmetrical synapse between an axon terminal and a dendrite (d). D: Another process juxtaposing a neuronal cell body (n) is contacting an axon terminal and an astrocytic process (a). m, putative microglia; ma, myelinated axon. Pockets of extracellular space are shown by the asterisks (*). Scale bars: 1μm.