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. 2014 Jan 10;7(3):640–648. doi: 10.3892/etm.2014.1484

Figure 6.

Figure 6

Resveratrol induces type II collagen and COX-2 expression via the ERK, p38 and Akt signaling pathways in rabbit articular chondrocytes. Rabbit articular chondrocytes were untreated or treated with the indicated concentrations of the inhibitors: (A) PD, an inhibitor of ERK; (B) SB, an inhibitor of p38; (C) LY, an inhibitor of PI3K/Akt; or (D) TB, an inhibitor of Akt for 1 h and then treated with 20 μM resveratrol for 24 h. Expression of pERK, pp38, pAkt, type II collagen and COX-2 was detected by western blot analysis. Expression of actin was used as the loading control. The data represent the results of a typical experiment from at least four independent experiments. PD, PD98059; SB, SB203580; LY, LY294002; TB, triciribine; COX-2, cyclooxygenase-2; ERK, extracellular signal-regulated kinase; PI3K, phosphoinositide 3-kinase.