Table III.
Results of the pooled and subgroup analyses of the included studies for the association between the UGRP1 -112G/A polymorphism and asthma risk.
| A vs. G | AA vs. GG | AA/GA vs. GG | AA vs. GA/GG | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
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| Variables | n | Cases/controls, n | OR (95% CI) | PEff | OR (95% CI) | PEff | OR (95% CI) | PEff | OR (95% CI) | PEff |
| Overall | 6 | 816/1,165 | 1.24 (0.95–1.61) | 0.11 | 1.76 (1.12–2.78) | 0.01 | 0.81 (0.59–1.13) | 0.22 | 1.70 (1.09–2.67) | 0.02 |
| Subgroup by ethnicity | ||||||||||
| Asian | 4 | 521/696 | 1.42 (1.06–1.90) | 0.02 | 2.08 (1.16–3.72) | 0.01 | 0.68 (0.45–1.02) | 0.06 | 1.90 (1.07–3.38) | 0.03 |
| Caucasian | 2 | 295/469 | 0.95 (0.66–1.39) | 0.81 | 1.40 (0.68–2.92) | 0.41 | 1.14 (0.82–1.59) | 0.42 | 1.43 (0.69–2.94) | 0.33 |
| Subgroup by atopy | ||||||||||
| Atopic | 2 | 278/390 | 1.12 (0.83–1.50) | 0.47 | 1.88 (0.82–4.30) | 0.13 | 0.97 (0.69–1.36) | 0.84 | 1.92 (0.85–4.35) | 0.12 |
| Mixed | 2 | 225/188 | 1.84 (1.08–3.13) | 0.02 | 2.09 (0.82–5.34) | 0.12 | 0.47 (0.23–0.97) | 0.04 | 1.75 (0.69–4.40) | 0.24 |
| NA | 2 | 313/587 | 1.02 (0.63–1.66) | 0.93 | 1.54 (0.79–3.00) | 0.21 | 1.04 (0.64–1.69) | 0.88 | 1.55 (0.80–3.01) | 0.19 |
UGRP1, uteroglobin-related protein 1 gene; NA, not available; N, number of studies; OR, odds ratio; CI, confidence interval; PEff, P-value of pooled effect; Mixed, data for atopic or non-atopic asthma patients were not able to be separately extracted.