TABLE I.

Clinical Characteristics of the Study Population

Characteristic	Chemotherapy, N = 123		MRD, N = 55		URD, N = 55		P
	N	%	N	%	N	%
Gender
Male	58	47	25	45	31	56
Female	65	53	30	55	24	44	0.44
Age at diagnosis
0–2 yo	58	47	13	24	9	16	<0.001
3–11 yo	34	28	21	38	24	44	0.09
12–21 yo	31	25	21	38	22	40	0.07
Racea
White	76	70	43	86	47	90	0.004
African American	23	21	4	8	1	2	0.002
Other	10	9	3	6	4	8	0.79
Unknown	14		5		3
Ethnicity
Hispanic	14	12	3	6	1	2	0.07
Not Hispanic	105	88	50	94	52	98
WBC (×103/μl)
<50,000	102	83	49	91	48	96	0.04
≥50,000	21	17	5	9	2	4
Weight categoryb
Underweight	3	4	7	14	4	8	0.14
Middleweight	55	74	38	76	41	80	0.73
Overweight	16	22	5	10	6	12	0.15
Unknown	49		5		4
Monosomy 7 or del7q
Negative	89	72	31	56	23	42	<0.001
Positive	34	28	24	44	32	58
Monosomy 5 or del5q
Negative	111	90	50	91	47	85	0.57
Positive	12	10	5	9	8	15
Abnormal 3q
Negative	107	87	50	91	52	95	0.29
Positive	16	13	5	9	3	5
t(6;9)
Negative	106	86	43	78	51	93	0.09
Positive	17	14	12	22	4	7
Complex cytogenetics
Negative	54	44	39	71	47	85
Positive	69	56	16	29	8	15	<0.001
Study
CIBMTR	0	0	27	53	55	100
POG 9421	36	29	5	9	0	0
CCG 2891	23	19	8	15	0	0
CCG 2961	30	24	11	20	0	0
COG AAML03P1	34	28	4	7	0	0
Stem cell source
Bone marrow	N/A		53	96	41	75
Peripheral blood			2	4	4	7
Cord blood					10	18
Time period
1989–1997	46	37	34	62	22	40	0.008
1998–2006	77	63	21	38	33	60

MRD, matched related donor; URD, unrelated donor; yo, years old.

^aPercentage distribution based on known values.

^bWeight category definitions: For Age ≥ 2 years old: underweight <5% bone mass index (BMI) percentile; middleweight 5–95% BMI percentile; overweight >95% BMI percentile; for age 1–2 years old: underweight <10% WT/LT percentile; middleweight 10–90% WT/LT percentile; overweight >90% WT/LT percentile; WT/LT, weight for length. Data for height/weight used at time of pre-conditioning or beginning of chemotherapy.