TABLE II.

Univariate Analysis of Patient- and Treatment-Related Factors Associated With OS, TRM and RR

	OS				TRM			RR
	N	HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
Treatment group
Poor-risk: chemotherapya	123	1			1			1
Poor-risk: MRD	55	0.97	0.63–1.51	0.90	1.79	0.66–4.82	0.25	0.74	0.48–1.14	0.17
Poor-risk: URD	55	0.97	0.62–1.51	0.89	3.77	1.65–8.62	0.002	0.37	0.21–0.64	<0.001
Age at diagnosis
3–11 yoa	79	1			1			1
0–2 yo	80	0.86	0.55–1.34	0.49	0.37	0.12–1.18	0.09	1.11	0.71–1.71	0.65
12–21 yo	74	1.49	0.98–2.27	0.07	1.81	0.83–3.97	0.14	0.98	0.63–1.53	0.93
Race
Not African Americana	183	1			1			1
African American	28	2.15	1.34–3.44	0.001	0.82	0.24–2.77	0.75	2.58	1.61–4.12	<0.001
Ethnicity
Not Hispanica	207	1			1			1
Hispanic	18	0.72	0.35–1.48	0.38	0.40	0.06–2.83	0.36	0.81	0.40–1.64	0.55
WBC at diagnosis
<50,000a	199	1			1			1
≥50,000	28	1.99	1.23–3.23	0.005	0.53	0.12–2.31	0.39	1.93	1.08–3.46	0.03
Weight category
Not overweighta	148	1			1			1
Overweight	27	1.07	0.62–1.87	0.80	1.52	0.56–4.12	0.41	0.83	0.45–1.53	0.55
Cytogenetics: monosomy 7 or del7q
Negativea	143	1			1			1
Positive	90	1.01	0.70–1.44	0.98	2.14	1.04–4.39	0.04	0.91	0.62–1.31	0.60
Cytogenetics: complexity ≥5
Negativea	140	1			1			1
Positive	93	0.88	0.61–1.27	0.50	0.44	0.19–1.01	0.05	0.98	0.68–1.42	0.92
Time period
1989–1997a	102	1			1			1
1998–2006	131	0.84	0.59–1.20	0.34	0.92	0.45–1.88	0.86	0.84	0.58–1.20	0.34

OS, overall survival; TRM, treatment-related mortality; RR, relapse risk; HR, hazard ratio; CI, confidence interval; MRD, matched related donor; URD, unrelated donor; yo, years old.

^aIdentifies reference group.