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. 2013 Nov 28;13(1):156–164. doi: 10.1111/acel.12165

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© 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Loss of NDG-4 causes increased stress resistance and lifespan. (A) RNAi against ndg-4 causes a significant increase in thermotolerance of rrf-3(pk1426) mutants. (B) ndg-4(lb108) mutants have significantly increased thermotolerance compared with wild-type N2 worms. (C) ndg-4(lb108) mutants have significantly increased lifespan compared with wild-type N2 worms. (D) ndg-4(sa529) mutants have significantly increased lifespan compared with wild-type N2 worms. (E) Lifespan of transheterozygous ndg-4(sa529/lb108) mutants, ndg-4(lb108) mutants, ndg-4(sa529) mutants and wild-type N2 worms. (F) Expression pattern of ndg-4 shown by transgenic expression of the transcriptional reporter construct Pndg-4::gfp. Bottom: Strong ndg-4 expression is seen in the intestine. Top: Enlargement showing Pndg-4::gfp expression in hypodermal cells in the nose region.