Table 1.
Table of the most commonly used cell lines appearing in AJP-Cell Physiology
| Cell Line | Sex | Description | Species | Year | Origin | Reference |
|---|---|---|---|---|---|---|
| 5637 | Male | Urinary bladder epithelium | Human | 1974 | C | (68, 69) |
| 3T3-L1 | Male | Embryo fibroblast | Mouse | 1962 | N | (84, 85) |
| 16HBE | Lung epithelial | Human | N | (46, 88) | ||
| A549 | Male | Lung epithelial | Human | 1972 | C | (79, 137) |
| A6 | Male | Kidney epithelial | Xenopus | 1965 | N | (165, 222) |
| A7r5 | Aorta smooth muscle | Rat | 1976 | N | (15, 183) | |
| AGS | Female | Stomach epithelial | Human | 1979 | C | (10, 11) |
| AML-12 | Male | Liver epithelial | Mouse | 1994 | N | (61, 282) |
| AML-193 | Female | Lymphoblast | Human | 1987 | C | (131, 229) |
| ARPE-19 | Male | Retinal pigmented epithelial | Human | 1986 | N | (62, 101) |
| BeWo | Female | Placenta | Human | 1966 | N | (193, 194) |
| BHK | Kidney fibroblast | Syrian hamster | 1961 | N | (146, 148) | |
| BT-549 | Female | Breast epithelial (ductal) | Human | 1978 | C | (112, 139) |
| BW5147.3 | T-lymphocyte | 1973 | C | (212, 213) | ||
| C2BBe1 | Male | Colonic epithelial cell (a CaCo-2 subclone) | Human | 1988 | C | (13, 200) |
| C2C12 | Myoblast | Mouse | 1977 | N | (285, 286) | |
| C6 | Glial cell | Rat | 1968 | N | (18, 138) | |
| C127 | Female | Mammary epithelial | Mouse | (141) | ||
| Ca SKI | Female | Cervical epithelial | Human | 1977 | C | (195, 291) |
| CaCo-2 | Male* | Colonic epithelial | Human | 1977 | C | (14, 107) |
| Calu-3 | Male* | Airway epithelial | Human | 1975 | C | (70, 94) |
| Capan-1 | Male* | Pancreatic epithelial | Human | (70, 71) | ||
| CCL-39 | Female | Fibroblast | Chinese hamster | 1964 | N | (214, 252) |
| CFPAC-1 | Male | Pancreatic epithelial | Human | 1990 | C | (155, 235) |
| CHO | Female | Ovarian epithelial | Chinese hamster | 1957 | N | (110, 207) |
| COS-7 | Kidney fibroblast | African green monkey | 1964 | N | (81) | |
| CPAE | Female | Pulmonary endothelial | Cow | 1979 | N | (23) |
| CRL-2234 | Male* | Hepatocyte | Human | 1990 | C | (189) |
| CV-1 | Male | Kidney fibroblast | African green monkey | 1964 | N | (105, 117) |
| DDT1-MF-2 | Male | Syrian hamster | 1983 | C | (178, 257) | |
| DU 145 | Male | Prostate epithelial | Human | 1978 | C | (187, 254) |
| ES-D3 | Embryonic stem cell | Mouse | 1985 | N | (56, 57) | |
| GH3 | Female | Pituitary epithelial | Rat | 1965 | C | (8, 258) |
| GH4C1 | Female | Pituitary epithelial | Rat | 1968 | C | (258, 259) |
| H441 | Male | Lung epithelial | Human | 1982 | C | (77, 179) |
| H460 | Male | Lung epithelial | Human | 1982 | C | (9, 30) |
| H4TG | Male | Liver epithelial | Rat | 1964 | C | (93, 203) |
| H9c2 | Myocardial myoblast | Rat | 1976 | N | (28, 116) | |
| H460 | Male | Lung epithelial | Human | 1982 | C | (9, 30) |
| HEK293 | Female | Embryonic kidney epithelial | Human | 1977 | N | (80, 83) |
| HEL299 | Male | Lung fibroblast | Human | 1982 | C | (201, 226) |
| HeLa | Female | Cervical epithelial | Human | 1953 | C | (78, 106) |
| HEP 3B | Female | Liver epithelial | Human | 1983 | C | (119, 120) |
| HEP G2 | Male | Liver epithelial | Human | 1994 | C | (119, 120) |
| Hepa 1–6 | Liver epithelial | Mouse | 1987 | C | (48, 49) | |
| HET-1A | Male | Esophageal epithelium | Human | 1986 | N | (162, 255) |
| hFOB | Female | Osteoblast | Human | 1997 | N | (95, 96) |
| HK-2 | Male | Kidney epithelial | Human | 1994 | N | (227) |
| HL-60 | Female | Premyeloblast | Human | 1979 | C | (75) |
| HOS | Female | Mixed osteoblast/epithelial | Human | 1975 | C | (153) |
| HPAF-II | Male* | Pancreatic epithelial | Human | 1982 | C | (114, 158) |
| HT-29 | Female | Colonic epithelial | Human | 1964 | C | (70, 271) |
| HuH7 | Male | Hepatocyte | Human | 1982 | C | (171) |
| HuTu80 | Male | Duodenal epithelial | Human | NA | C | (232) |
| IB3–1 | Lung epithelial | Human | 1992 | N | (67, 297) | |
| IEC-6 | Male | Small intestine epithelial | Rat | 1978 | N | (208, 209) |
| IMR-90 | Female | Lung fibroblast | Human | 1977 | N | (65, 176) |
| Jurkat | Male | Lymphoblast | Human | 1984 | C | (234, 276) |
| K562 | Female | Bone marrow lymphoblast | Human | 1975 | C | (118, 152) |
| KATO III | Male* | Gastric carcinoma mixed | Human | 1978 | C | (238) |
| KG-1 | Male | Macrophage | Human | 1978 | C | (121, 122) |
| LLC-PK1 | Male | Kidney epithelial | Pig | 1979 | N | (103, 198) |
| LnCAP | Male | Prostate epithelial | Human | 1977 | C | (102) |
| LS 174T | Female | Colonic epithelial | Human | 1976 | C | (262) |
| Ltk-11 | Male | Fibroblast | Mouse | 2004 | N | (124) |
| Mc3T3-E1 | Preosteoblast | Mouse | 1981 | N | (273) | |
| MCF-7 | Female | Breast epithelial | Human | 1970 | C | (27, 250) |
| MDA-MB-468 | Female | Breast epithelial | Human | 1977 | C | (192, 243) |
| MDCK | Female | Kidney epithelial | Dog | 1958 | N | (76) |
| MEF-1 | Fibroblast | Mouse | 1993 | N | (292) | |
| MG-63 | Male | Bone fibroblast | Human | 1977 | C | (21) |
| MIA-PaCa-2 | Male* | Pancreatic epithelial | Human | 1975 | C | (293) |
| mIMCD-3 | Kidney epithelial | Mouse | 1991 | N | (216) | |
| MKN45 | Female | Gastric carcinoma | Human | NA | C | (170) |
| NRK | Kidney epithelial | Rat | NA | N | (50) | |
| NuLi-1 | Male | Lung epithelial | Human | 2000 | N | (294) |
| OK | Female | Kidney epithelial | Opossum | 1978 | N | (126) |
| PC-3 | Male* | Prostate epithelial | Human | 1979 | C | (42, 108) |
| PC12 | Male | Adrenal gland | Rat | 1976 | N | (86) |
| pRSV-T | Male | Epithelial | Human | 1997 | N | (127) |
| PNT1A | Male | Prostate epithelial | Human | 1991 | N | (47) |
| RPE-1 | Female | Retina pigment epithelial | Human | 1998 | N | (152) |
| Saos-2 | Female | Bone epithelial | Human | 1975 | C | (69, 221) |
| SBC-3 | Male | Lung carcinoma | Human | 1997 | C | (123, 287) |
| SC2G | Female | Breast epithelial | Mouse | 1964 | C | (163, 164) |
| SCC-9 | Male | Tongue | Human | 1981 | C | (219) |
| SH-SY5y | Female | Bone marrow epithelial | Human | 1970 | C | (20, 225) |
| SK-MEL-2 | Male | Skin melanoma | Human | 1975 | C | (43) |
| SK-MEL-24 | Male | Skin melanoma | Human | 1976 | C | (71, 204) |
| SW620 | Male* | Colon epithelial | Human | 1976 | C | (69, 136) |
| SW 982 | Female | Synovium | Human | 1974 | C | (69, 288) |
| T84 | Male* | Colonic epithelia | Human | 1980 | C | (12, 54, 169) |
| TCCSUP | Female | Urinary bladder epithelia | Human | 1978 | C | (87, 175) |
| THP-1 | Male | Monocyte | Human | 1982 | C | (248, 264) |
| U-87 | Male* | Glioma | Human | 1966 | C | (69, 205) |
| U-937 | Male* | Monocyte | Human | 1974 | C | (125) |
| UMR-106 | Bone epithelial | Rat | 1976 | C | (149, 191) | |
| Y79 | Female | Retinoblastoma | Human | 1974 | C | (151) |
Where possible, references include the first descriptions of the cell lines. Cells were derived from “C,” cancerous tissue or “N,” noncancerous tissue (usually virally transformed).
*
Cells derived from human “male” tissues that now express only amelogenin-X and no amelogenin-Y. NA, original deposition date could not be determined. This table is not intended to be a comprehensive data set, but rather to highlight the cell lines that are routinely used by authors in AJP-Cell Physiology. For a larger database, the reader is directed to such sites as American Tissue Type Collection (ATTC.org).