Table 1.
Baseline |
7 days post-MI |
28 days post-MI |
|||||||
---|---|---|---|---|---|---|---|---|---|
Sham | MI+PBS | MI+MSC | Sham | MI+PBS | MI+MSC | Sham | MI+PBS | MI+MSC | |
HR, beats/min | 691 ± 7 | 646 ± 34 | 666 ± 13 | 716 ± 8 | 692 ± 16 | 678 ± 7 | 777 ± 43 | 799 ± 69 | 689 ± 9*† |
IVSd, mm | 0.79 ± 0.01 | 0.77 ± 0.01 | 0.76 ± 0.01 | 0.84 ± 0.01 | 0.81 ± 0.05 | 0.78 ± 0.02* | 0.77 ± 0.02 | 0.77 ± 0.03 | 0.81 ± 0.01 |
LVIDd, mm | 2.93 ± 0.05 | 3.09 ± 0.10 | 3.33 ± 0.09 | 3.02 ± 0.04 | 4.44 ± 0.32* | 3.93 ± 0.28* | 2.98 ± 0.04 | 4.76 ± 0.33* | 4.35 ± 0.14* |
LVPWd, mm | 0.78 ± 0.02 | 0.76 ± 0.03 | 0.74 ± 0.01 | 0.77 ± 0.02 | 0.77 ± 0.07 | 0.80 ± 0.02 | 0.74 ± 0.03 | 0.60 ± 0.06* | 0.83 ± 0.02*† |
IVSs, mm | 0.93 ± 0.02 | 0.89 ± 0.02 | 0.93 ± 0.02 | 0.95 ± 0.03 | 0.91 ± 0.04* | 0.93 ± 0.02 | 0.88 ± 0.02 | 0.81 ± 0.03 | 0.93 ± 0.02† |
LVIDs, mm | 1.45 ± 0.03 | 1.53 ± 0.06 | 1.73 ± 0.06 | 1.53 ± 0.03 | 3.36 ± 0.29* | 2.86 ± 0.14*† | 1.52 ± 0.03 | 3.69 ± 0.32* | 2.94 ± 0.16*† |
LVPWs, mm | 0.97 ± 0.02 | 0.97 ± 0.02 | 1.02 ± 0.02 | 0.99 ± 0.03 | 0.86 ± 0.07* | 0.96 ± 0.02 | 0.92 ± 0.03 | 0.75 ± 0.07* | 1.01 ± 0.02*† |
Values are means ± SE; n = 6–14 mice/group. HR, heart rate; IVSd, interventricular septal thickness in diastole; LVIDd, left ventricle (LV) end-diastolic dimension; LVPWd, LV posterior wall thickness in diastole; IVSs, interventricular septal thickness in systole; LVIDs, LV end-systolic dimension; LVPWs, LV posterior wall thickness in systole; MI, myocardial infarction; PBS, phosphate-buffered saline; MSC, mesenchymal stem cell.
P < 0.05 vs. Sham at specified time point.
P < 0.05 vs. MI+PBS at specified time point.