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Perfused SRGs. Mean maximum chloride secretion (μeq·h−1·g−1 ± SE) with nonspecific (IBMX) and isotype-specific PDE inhibitors. Only IBMX, a nonspecific PDE inhibitor, and PDE-3 specific inhibitors (cilostamide, amrinone, and milrinone) increased chloride secretion above basal values. Total n = 55 perfusions, n = 3–19 per group. ***P < 0.001, **P < 0.01, *P < 0.05, all compared with basal.
