Fig. 4.

Mitochondrial Ogg1 overexpression prevents loss of mitochondrial DNA-encoded proteins under oxidative stress conditions. A: representative Western blots of ND4 and COX1 mtDNA-encoded subunits and total OXPHOS proteins [from electron transport chain (ETC) complexes I–V]. B–G: graphs represent the fold change of protein levels relative to control. Bars indicated means ± SE. Experiments were repeated 3 times, and assays were done in triplicate. Signal intensities were normalized to VDAC. *P < 0.05 vs. control.