Fig. 7.

Effects of mitochondrial Ogg1 overexpression on fission and fusion proteins under oxidative stress conditions. A: representative Western blots of fission proteins [DRP1, p-DRP1(ser616), FIS1, and Bax] and fusion proteins [OPA1, MFN1, MFN2, p-DRP1(ser637)]. Immunoblot analysis showed that mitochondrial fission and mitochondrial fusion proteins were reduced and increased, respectively, in Adv-Ogg1 transduced cells. B–H: graphs represent the fold change of protein levels relative to control. Bars indicated means ± SE. Experiments were repeated 3 times, and assays were done in triplicate. *P < 0.05, **P < 0.01.