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. 2013 Nov 27;306(3):C263–C278. doi: 10.1152/ajpcell.00381.2012

Fig. 15.

Fig. 15.

Effect of the inositol triphosphate (IP3) receptor inhibitor 2-aminoethoxydiphenyl borate (2-APB) on PGE2-induced Isc in mIMCD-K2 cells. A: representative trace shows the Isc response to the addition of 2-APB (2 × 10−4 M) to both sides on PGE2-induced Isc (IscPGE2). B: average Isc responses to sequential addition of amiloride, PGE2 (to the basal bath), and 2-APB. Values are means ± SE (n = 11 filters). *Value significantly different from that in amiloride-treated cells; #value significantly different from IscPGE2 in control cells. C: inhibition of PGE2-induced Isc (ΔIscPGE2) after apical addition of CI-172 and FFA to cells pretreated with vehicle (open bars) or 2-APB (solid bars). Values are means ± SE (n = 5–6 filters). *Values significantly different from ΔIscPGE2 in vehicle-treated cells. D: percentage of inhibition of PGE2-induced Isc (IscPGE2) after apical addition of CFTR inhibitor-172 or FFA to cells pretreated with vehicle or 2-APB. Values are means ± SE (n = 5–6 filters). *Values significantly different from percent decrease in IscPGE2 in vehicle-treated cells.