Table 1.

Predicted NF-κB sequences in the rat CXCL1 and CXCL2 proximal gene promoters

CXCL1	CXCL2	CXCL1/CXCL2
GGGAATTTCCC	GGGGCTTTTCC	−83/−54
GGGAAACACCC	GGGGATTTCCC	−102/−73
GGAAGTTCCC	GGAAGTTCCC	−641/−640
TGGACTTTCC	ND	−709/ND
GGGATTTGCT	ND	−1299/ND

For each gene, TFSEARCH (v. 1.3) was used to analyze ∼1.5 kb of the upstream promoter region (relative to the transcriptional start site) for recognized κB genomic regulatory sequences. Predicted κB sequences for each gene are shown in the left (CXCL1) and middle (CXCL2) columns, with a comparison of relative positioning of each detected κB site shown at the right. Bolded sequence is a consensus κB response element detected in both genes at almost identical genomic positions. ND, no comparable site detected by the software algorithm within that region. Consensus κB sequence: GGRRNNYYCC, where R is purine, N is any nucleotide, and Y is pyrimidine.