Treatment of nonalcoholic fatty liver disease with metformin, exercise training, or the combination. Intrahepatic triglyceride (TG) accumulation demonstrated by hematoxylin and eosin stain (A), biochemical analysis (B), liver diacylglycerols (DAGs; C), and serum alanine aminotransferase (ALT) concentrations (D). All values are means ± SE. Values with different letters are significantly different; P < 0.05.