Table 4.
Enriched BAT proteomic pathways in k-means patterns of spring transition 13-lined ground squirrels determined from identified protein spots differing by Tukey HSD from either spring (SpC or SpW) ground squirrels, or any heterothermic winter groups
| Annotation Term | Score | Fold | Genes |
|---|---|---|---|
| Spring Transition Pathways Already in Terminally Aroused Form (Decreased Abundance) | |||
| Coenzyme binding | 7.1 | 26 | ACADVL, ALDH6A1, ACADM, OGDH, HADH, IDH3A, HADHA, HADHB, ETFA |
| Mitochondrial membrane | 6.3 | 12 | ACADVL, COX7A2, CKMT1B, IMMT, PHB, HSPD1, OGDH, HADH, HADHA, HADHB |
| Organelle lumen | 5.6 | 4 | GRPEL1, ACADM, PHB, OGDH, IDH3A, HADHA, HADHB, ACADVL, LONP1, C1QBP, VCP, HSPD1, HSPA5, HADH, ETFA |
| Fatty acid binding | 4.6 | 68 | ALDH6A1, FABP3, FABP4, HADHA, HADHB |
| Fatty acid metabolism | 4.3 | 55 | ACADVL, ACADM, HADH, HADHA, HADHB |
| Adenyl nucleotide binding | 3.4 | 4 | ACADVL, TRAP1, LONP1, GRPEL1, ACADM, CKMT1B, VCP, HSPA5, HSPD1, SUCLA2, ETFA |
| Endopeptidase activity regulation | 1.8 | 21 | VCP, HSPA5, HSPD1 |
| Spring Transition Pathways Already in Terminally Aroused Form (Increased Abundance) | |||
| Mitochondrion | 3.7 | 6 | GPD2, ACAA2, SHMT2, NDUFS8, ACAT1, IDH3A, PCCA |
| 14-3-3 | 3.2 | 649 | YWHAZ, YWHAB, YWHAQ, YWHAE |
| Complex assembly | 2.8 | 7 | PPP2R1A, FGB, FKBP4, NDUFS8, YWHAB, CDA |
| Phosphate metabolism regulation | 1.8 | 6 | PRKAR2B, PPP2R1A, YWHAB, FABP4, YWHAE |
| Cytoplasmic vesicle | 1.7 | 5 | YWHAZ, PRDX6, FGB, YWHAB, YWHAE |
| Apoptosis regulation | 1.5 | 4 | PPP2R1A, YWHAZ, YWHAB, YWHAE, GSTP1 |
Note: Enrichments determined by DAVID. “Score” denotes DAVID enrichment score (significance set >1.3). “Fold” denotes pathway fold enrichment. Redundant pathways and those contained as subsets within broader pathways were removed.