Fig. 2.

Chronic glucosuric response to SGLT2 inhibitor is enhanced 1.5- to 2-fold in Sglt1−/− vs. WT mice, associated with greater increases in food and fluid intake. Depicted are effects of empagliflozin application (300 mg/kg of diet) for 3 wk on urinary glucose/creatinine ratios (A), absolute levels of and changes in blood glucose (B), and changes in food intake (C), fluid intake (D), and body weight (E). Spontaneous urine collections were made, and blood was collected by tail snip in awake mice; food and fluid intake was measured in regular cages; n = 9–11/group. *P < 0.05 vs. WT by ANOVA and unpaired Student's t-test. #P < 0.05 vs. day 0 same group by paired Student's t-test.