Fig. 10.

Na⁺/H⁺ exchanger NHE-3 expression in normal and acid-loaded diet C and CD-Rhbg/Rhcg-KO kidneys. A: immunoblot analysis of NHE-3 in the cortex and OM of CD-Rhbg/Rhcg-KO and C mice on a normal diet and when acid loaded. B: quantification of NHE-3 expression. CD-Rhbg/Rhcg-KO did not alter NHE-3 expression in either the cortex or OM in mice on a normal diet. In the cortex, NHE-3 expression was significantly greater in acid-loaded CD-Rhbg/Rhcg-KO than in acid-loaded C mice and CD-Rhbg/Rhcg-KO fed a normal diet. Values are means ± SE; n = 4/group.