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. 2013 Dec 11;306(4):F389–F400. doi: 10.1152/ajprenal.00176.2013

Fig. 5.

Fig. 5.

Immunodot analysis of Rhbg and Rhcg expression. Top: summary of Rhcg protein expression in the cortex and OM. In mice with intact Rhcg expression, acid loading increases Rhcg protein expression in the OM. In mice with combined collecting duct-specific Rhbg and Rhcg deletion, Rhcg expression is greatly diminished and is not altered by acid-loading. Bottom: summary of Rhbg protein expression. In mice with intact Rhbg expression, metabolic acidosis significantly increases Rhbg expression in both the cortex and OM. In mice with collecting duct-specific Rhbg and Rhcg deletion, basal Rhbg expression is significantly decreased (residual expression reflects expression in CNT and DCT cells) and is not altered by acid loading.