Table 1.
Physiological parameters under basal conditions
| Parameter | CD-Rhbg/Rhcg-KO | C | P Value |
|---|---|---|---|
| Urine ammonia, μmol/day | 169.3 ± 15.8 (6) | 179.4 ± 39.8 (6) | NS |
| Urine pH | 6.04 ± 0.07 (6) | 6.11 ± 0.08 (6) | NS |
| Urine titratable acid, μmol/day | 94.7 ± 12.2 (6) | 84.5 ± 9.3 (6) | NS |
| Serum creatinine, mg/dl | 0.103 ± 0.010 (6) | 0.101 ± 0.004 (6) | NS |
| Creatinine clearance, μl/min | 283.3 ± 38.5 (6) | 209.3 ± 36.0 (6) | NS |
| Urine volume, ml/day | 1.86 ± 0.22 (6) | 2.05 ± 0.31 (6) | NS |
Values are means ± SE. Numbers in parentheses are numbers of animals in each group. CD-Rhbg/Rhcg-KO, collecting duct-specific Rhbg and Rhcg glycoprotein deletion; C, control; NS, not significant.