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Macrophage infiltration is significantly decreased on day 3 of IRI following treatment with PD 0332991. A: confocal micrographs of control kidney and injured kidney on day 3 of IRI treated with vehicle or PD 0332991 1 h before surgery. Macrophage marker F4/80 in green. B: percentage of medullary kidney positive for F4/80 is significantly decreased in subjects treated with PD 0332991. Analyzed by 2-way ANOVA followed by Bonferroni's posttest. ***P < 0.001. CLK, contralateral kidney.
