Table 3.
Best evidence of linkage with obesity-related traits derived from genome-wide linkage studies undertaken in the Quebec Family Study
| Location | Marker | Trait | Gene | Reference |
|---|---|---|---|---|
| 1q43 | D1S184 | BMI, FM, % body fat | RGS7 | [27] |
| 15q26.2-q26.3 | IGF1R CA repeat | FFM | IGF1R | [28] |
| 12q24.3 | D12S2078 | ASF adjusted for FM | HNF1 | [29] |
| 3q27.3 | D3S1262 | EI, Lipid, CHO | ADIPOQ | [30] |
| 15q24-q25 | D15S206 | Disinhibition, Hunger | NMB | [31] |
| 2p22-p16 | D2S2347 | Inactivity | NA | [32] |
| 3q26.1 | D3S1763 | RMR | GLUT2 | [11] |
| 14q22.2 | D14S587 | RQ | NA |
Traits: FM = fat mass; FFM = fat-free mass; ASF = abdominal subcutaneous fat; EI = energy intake; Lipid = lipid intake; CHO = carbohydrate intake; RMR = resting metabolic rate; RQ = respiratory quotient.
Genes: RGS7 = regulator of G-protein signaling 7; IGFR1 = insulin-like growth factor 1 receptor; ADIPOQ = adiponectin; NMB = neuromedin-B; GLUT2 = Glucose transporter 2.
NA: no gene could be identified