Table 5.
Frequency of NR1H4 promoter methylation with different colon tumor subtypes
| NR1H4 meth β > 0.6 | NR1H4 meth β < 0.6 | Frequency β > 0.6 | Fisher Exact Test | |
|---|---|---|---|---|
| Total | 26 | 210 | 0.124 | |
| KRAS wt | 15 | 113 | 0.682 | 0.37 |
| KRAS mut | 7 | 84 | 0.574 | |
| N/A | 4 | 13 | ||
| MSI-H | 6 | 25 | 0.231 | 0.23 |
| MSI-L | 18 | 148 | 0.120 | |
| MSS | 2 | 36 | ||
| N/A | 0 | 1 | ||
| CIMP-H | 6 | 30 | 0.231 | 0.76 |
| CIMP-L | 7 | 46 | 0.143 | |
| Cluster3 | 8 | 69 | ||
| Cluster4 | 5 | 65 | ||
| N/A | 0 | 0 | ||
| Hypermut | 5 | 29 | 0.227 | 0.35 |
| Nonhypermut | 17 | 168 | 0.147 | |
| N/A | 4 | 13 |
meth, Methylation; wt, wild-type, mut, mutated; N/A, not applicable; MSI-H, microsatellite instability-high; MSI-L, microsatellite instability-low; MSS, microsatellite stability; CIMP-H, CpG island methylator phenotype-high; CIMP-L, CpG island methylator phenotype-low; hypermut, hypermutated; Nonhypermut, nonhypermutated.