Fig. 2.

Effects of RTK inhibition on hepatic production and circulating levels of endothelin-1 (ET-1) after CBDL. A: representative images of immunohistochemical staining for ET-1 in liver (bile ducts shown by arrows). B: liver ET-1 mRNA levels and circulating ET-1 levels. Values are expressed as means ± SE (n = 8 animals for each group). C: graphic summaries of ET-1 mRNA and supernate protein levels in VEGF-A (15 ng/ml)-treated normal rat cholangiocytes in the presence or absence of U0126 (10 μM) for 15 h. *P < 0.05 compared with sham. ‡P < 0.05 compared with CBDL.