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. 2014 Feb 11;5:31. doi: 10.3389/fphys.2014.00031

Figure 1.

Figure 1

More recently, another family of proteins, termed pannexins (Panxs), has been identified. These proteins share similar membrane topology but no sequence homology with Cxs. In turn, sequence homology is given to the invertebrate gap junction protein Innexins. Pannexins form unique, multimeric membrane channels with pharmacosensitivity partially overlapping with that of Cx hemichannels.