Table 1.
Classification of search results for recent clinical trials of pharmacokinetics and pregnancy.
| Year | Total (PubMed + OPRU) | Acute/subacute |
Chronic |
||||
|---|---|---|---|---|---|---|---|
| Intra-partum | Late ante-partum | ARVs ante-partum | Other ID ante-partum | Vitamins/minerals ante-partum | Other medications ante-partum | ||
| 2013 (1/1–8/31 only) | 9 | 3 | 2 | 2 | 0 | 1 | 1 |
| 2012 | 14 | 2 | 2a | 4 | 1 | 1a | 4 |
| 2011 | 17 | 4 | 0 | 4 | 4 | 0 | 5 |
| 2010 | 11 | 4b | 1 | 1 | 2 | 0 | 3 |
| 2009 | 16 | 3 | 1 | 2 | 2 | 1 | 7b |
| 2008 | 14 | 3a | 1 | 3 | 2 | 0 | 5a |
| Total (1/2008–8/2013) | 81 | 19 | 7 | 16 | 11 | 3 | 25 |
Data for 2013 only includes those articles indexed for MEDLINE as “clinical trial” (publication type) by August 31, 2013. The “intra-partum” category includes medications given at the time of delivery, typically for pain control or infectious disease prophylaxis. The “late ante-partum” category includes pharmacotherapy given for pre-eclampsia; management of syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP); or to induce tocolysis. The remaining categories include medications administered earlier in pregnancy (i.e., prior to labor/delivery) only.
ARVs, antiretrovirals; ID, infectious disease. References for each column: intra-partum (5–23), late ante-partum (24–30), ARVs (31–46), other ID (47–57), vitamins/minerals (58–60), other medications (61–85).
aOne study in this category did not measure drug concentrations.
bTwo studies in this category did not measure drug concentrations.