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. 2013 Dec 19;306(4):G328–G337. doi: 10.1152/ajpgi.00203.2013

Fig. 2.

Fig. 2.

Effect of tropomyosin-related kinase B (TrkB) antagonist K252a on BDNF-mediated augmentation of intestinal longitudinal muscle-myenteric plexus (LM-MP) contraction induced by CCh. The Trk receptor inhibitor K252a (1 μM) did not significantly affect the contraction induced by 10 μM CCh. Incubation of LM-MP strips with 10 nM of BDNF resulted in a significant 88% augmentation of contraction induced by 10 μM CCh. K252a incubation for 15 min before and during BDNF incubation resulted in an inhibition of the augmentation of CCh-induced contraction by BDNF. The contraction in the presence of BDNF plus K252a was not significantly different from that elicited by 10 μM CCh alone. Data represent the percent of contraction relative to CCh. Values are means ± SE. *P < 0.05, n = 7.