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TrkB activation by selective agonists enhances the contraction induced by CCh. Activation of TrkB with selective synthetic agonists led to significant increase in contraction induced by 10 μM CCh similar to that elicited by BDNF (cf. Figs. 2 and 3). Application of 1 μM of either LM22A4 or 7,8-dihydroxyflavone for 60 min augmented CCh-induced contraction. Data represent percentage of control, preincubation CCh-induced contraction. Values are means ± SE. *P < 0.05, n = 6.
