Table 1.

Effect of chronic ethanol consumption and genotype on body, liver, and serum measurements

Group	Body Wt, g	Liver Wt, g	Liver Wt/Body Wt, %	Serum ALT, IU/l	Serum TGs, mg/dl	Liver TGs, mg/mg protein
WT Con	29.3 ± 1.0	1.30 ± 0.08	4.5 ± 0.20	34 ± 2.5	86 ± 6.4	1.5 ± 0.38
WT EtOH	32.2 ± 0.8a	1.49 ± 0.06	4.6 ± 0.14	50 ± 6.8a	142 ± 15a	3.5 ± 0.40a
CypD−/− Con	29.0 ± 2.0	1.45 ± 0.10	5.0 ± 0.13	40 ± 6.0	78 ± 16	1.7 ± 0.20
CypD−/− EtOH	31.5 ± 1.2	1.80 ± 0.13b,c	5.7 ± 0.30b,c	65 ± 10	187 ± 26b,c	5.3 ± 0.70b,c
	2-Factor ANOVA (P values)
Diet	0.028	0.028	0.103	0.007	<0.001	<0.001
Genotype	0.383	0.054	0.001	0.850	0.168	0.109
Interaction (diet × genotype)	0.506	0.369	0.101	0.672	0.088	0.113

Values are means ± SE; n = 6–8 mice per group.

WT, wild-type; CypD^−/−, cyclophilin D-null; Con, control diet; EtOH, ethanol-containing diet; ALT, alanine aminotransferase; TGs, triglycerides.

^aResults from post hoc statistical analyses P < 0.05 vs. WT Con;

^bP < 0.05 vs. CypD^−/− Con;

^cP < 0.05 vs. WT EtOH.