Table 5.
Fecal metabolite markers of FMT
ID | [M-H]− | Formula | Identity | Effect of FMT |
---|---|---|---|---|
I | 407.2798 | C24H40O5 | Cholic acid | ↓ |
II | 391.2848 | C24H40O4 | Chenodeoxycholic acid | ↓ |
III | 391.2848 | C24H40O4 | Deoxycholic acid | ↑ |
IV | 375.2899 | C24H40O3 | Lithocholic acid | ↑ |
V | 391.2848 | C24H40O4 | Isodeoxycholic acid | ↑ |
VI | 514.2839 | C26H45NO7S4 | Taurocholic acid | ↓ |
VII | 498.2889 | C26H45NO6S | Taurochenodeoxycholic acid | ↓ |
VIII | 464.2817 | C26H43NO6 | Glycocholic acid | ↓ |
IX | 448.3063 | C26H43NO5 | Glycochenodeoxycholic acid | ↓ |
Major primary and secondary bile acids and conjugates of primary bile acids (I–IX) were identified as metabolite markers contributing to separation of pre-FMT samples from post-FMT and donor samples in metabolomic analysis. [M-H]−, mass-to-charge ratio of deprotonated metabolite; ↑, increased after FMT; ↓, decreased after FMT.