Table 3.
Hemodynamic and gas exchange variables during hypoxia
| Healthy |
MetSyn |
|||
|---|---|---|---|---|
| Placebo | Indo | Placebo | Indo | |
| MBP, mmHg* | ||||
| Baseline | 90 ± 2 | 95 ± 2 | 102 ± 3 | 105 ± 2 |
| 90% | 94 ± 2 | 94 ± 2 | 105 ± 3 | 104 ± 3 |
| 80% | 92 ± 3 | 95 ± 2 | 105 ± 3 | 104 ± 4 |
| PetCO2, mmHg* | ||||
| Baseline | 39 ± 1 | 39 ± 0 | 38 ± 1 | 37 ± 1 |
| 90% | 39 ± 0 | 39 ± 0 | 38 ± 1 | 37 ± 1 |
| 80% | 39 ± 0 | 39 ± 0 | 38 ± 1 | 38 ± 1 |
| SpO2, %† | ||||
| Baseline | 98 ± 0 | 98 ± 0 | 98 ± 0 | 98 ± 0 |
| 90% | 90 ± 0 | 90 ± 0 | 90 ± 0 | 90 ± 0 |
| 80% | 80 ± 0 | 81 ± 0 | 80 ± 0 | 80 ± 0 |
| FiO2, %† | ||||
| Baseline | 19 ± 0 | 19 ± 0 | 20 ± 0 | 20 ± 0 |
| 90% | 12 ± 0 | 12 ± 0 | 13 ± 0 | 12 ± 0 |
| 80% | 9 ± 0 | 10 ± 0 | 10 ± 0 | 9 ± 0 |
| MCAv, cm/s*†‡ | ||||
| Baseline | 73 ± 5 | 48 ± 2 | 66 ± 4 | 44 ± 3 |
| 90% | 79 ± 5 | 51 ± 3 | 68 ± 5 | 48 ± 3 |
| 80% | 85 ± 5 | 55 ± 3 | 71 ± 5 | 54 ± 3 |
| ΔMCAv, cm/s†‡ | ||||
| 90% | 6 ± 1 | 3 ± 1 | 2 ± 1 | 4 ± 1 |
| 80% | 11 ± 2 | 8 ± 1 | 8 ± 2 | 12 ± 1 |
| Indo Change ΔMCAv* | ||||
| 90% | −3 ± 1 | 2 ± 1 | ||
| 80% | −4 ± 2 | 4 ± 2 | ||
| CVCi, cm·s−1 ·mmHg−1*†‡§ | ||||
| Baseline | 82 ± 5 | 51 ± 3 | 65 ± 5 | 42 ± 3 |
| 90% | 86 ± 6 | 55 ± 3 | 65 ± 5 | 46 ± 3 |
| 80% | 94 ± 7 | 59 ± 3 | 68 ± 5 | 53 ± 3 |
| ΔCVCi, cm·s−1 ·mmHg−1†‡§ | ||||
| 90% | 3 ± 1 | 4 ± 1 | 0 ± 1 | 4 ± 1 |
| 80% | 11 ± 2 | 8 ± 2 | 5 ± 2 | 13 ± 2 |
| Indo Change ΔCVCi* | ||||
| 90% | 0 ± 1 | 4 ± 1 | ||
| 80% | −3 ± 2 | 7 ± 3 | ||
Values are means ± SE. Indo, indomethacin; MBP, mean blood pressure; FiO2, fraction of inspired oxygen; Indo Change ΔMCAv, magnitude of change of ΔMCAv after Indo; Indo Change ΔCVCi, magnitude of change of ΔCVCi after Indo.
*
Main effect of group,
†
main effect of hypoxia,
‡
main effect of Indo,
§
group × Indo interaction (P < 0.05).