Table 4.
Hemodynamic and gas exchange variables during hypercapnia
| Healthy |
MetSyn |
|||
|---|---|---|---|---|
| Placebo | Indo | Placebo | Indo | |
| MBP, mmHg* | ||||
| Baseline | 91 ± 2 | 94 ± 2 | 102 ± 3 | 104 ± 3 |
| Hypercapnia | 94 ± 2 | 95 ± 2 | 105 ± 3 | 108 ± 4 |
| PetCO2, mmHg*† | ||||
| Baseline | 39 ± 0 | 38 ± 0 | 38 ± 1 | 37 ± 1 |
| Hypercapnia | 49 ± 0 | 48 ± 0 | 47 ± 1 | 47 ± 1 |
| SpO2, %*† | ||||
| Baseline | 98 ± 0 | 98 ± 0 | 98 ± 0 | 98 ± 0 |
| Hypercapnia | 100 ± 0 | 100 ± 0 | 99 ± 0 | 99 ± 0 |
| MCAv, cm/s†‡ | ||||
| Baseline | 71 ± 3 | 48 ± 3 | 65 ± 4 | 46 ± 3 |
| Hypercapnia | 87 ± 4 | 56 ± 3 | 84 ± 5 | 56 ± 3 |
| ΔMCAv, cm/s‡ | ||||
| Hypercapnia | 17 ± 1 | 8 ± 1 | 20 ± 2 | 10 ± 1 |
| Indo Change ΔMCAv | ||||
| Hypercapnia | −9 ± 1 | −9 ± 2 | ||
| CVCi, cm·s−1·mHg−1*†‡ | ||||
| Baseline | 80 ± 5 | 51 ± 3 | 64 ± 4 | 44 ± 2 |
| Hypercapnia | 94 ± 5 | 59 ± 4 | 81 ± 5 | 52 ± 3 |
| ΔCVCi, cm·s−1·mmHg−1‡ | ||||
| Hypercapnia | 15 ± 1 | 8 ± 1 | 16 ± 1 | 8 ± 1 |
| Indo Change ΔCVCi | ||||
| Hypercapnia | −8 ± 1 | −9 ± 1 | ||
Values are means ± SE.
*
Main effect of group,
†
main effect of hypercapnia,
‡
main effect of Indo (P < 0.05).