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Efficacy of the P2X receptor blockade in freely perfused rats. Pyridoxal phosphate-6-azophenyl-2′,4′-disulfonic acid (PPADS; 10 mg/kg; A) significantly attenuated the pressor response to α,β-methylene ATP (10 μg/kg), whereas sterile water (B), the vehicle, had no effect. MAP, mean arterial pressure. *P < 0.05, significantly smaller pressor response from the pressor response before PPADS.
